There is no single answer to this question, because what works best for some men with ED doesn’t necessarily work as well for others. And for some, the use of any of the PDE5-inhibiting drugs may be inappropriate because of underlying health conditions or because of possible conflicts with other medications they are taking.
All of the PDE5 inhibitors — Viagra, Cialis, Levitra, Staxyn, and Stendra — work in pretty much the same way, although there are some slight differences in how quickly they take effect and some more significant differences in how long they are effective.
If you’re looking for a longer-lasting oral ED drug, your best bet is probably Cialis for Use as Needed, which can be effective for as long as 36 hours, earning it the nickname of the “weekend pill.”
Other medications include those used in penile injection and MUSE therapies. Injected into the erectile tissue of the penis or absorbed through the linings of the urethra, these medications include alprostadil, papaverine, and phenolamine.