The problem with taking SSRIs to treat premature ejaculation is that, after all, they’re specifically designed to alter your brain chemistry, and some men believe that is too great a risk. By inhibiting the reuptake of serotonin in the brain, these drugs cause levels of serotonin in the brain to increase, and this is an effective treatment for clinical depression for many people.
Other side effects (besides delayed ejaculation) of SSRIs include sleepiness, dry mouth, nausea, insomnia, agitation, dizziness, and headaches. Often, when people are prescribed SSRIs for depression, there is a period of trial and effort before finding the right drug and the right dosage that offers the most favorable trade-off between effectiveness and side effects. You might have to go through something similar to figure out the right SSRI and dosage to help with premature ejaculation without causing other problems.
Finally, another issue with SSRIs is that taking them over long periods and then stopping “cold turkey” can cause unpleasant symptoms like sensory disturbances, nausea, insomnia, and irritability.