It’s a complex connection. Creatine contains a substance called ATP, which helps the body produce the energy needed for muscle contractions. But when a person relies upon creatine on a daily, long-term basis, it can affect the body’s normal hormonal production system.
Basically, long-term overload of creatine can stress the kidneys’ and liver’s detoxification systems. In turn, these systems produce less of the enzymes necessary for hormone synthesis. Once hormone production slows, to things happen: the body has a harder time sending brain signals needed for producing an erection, and sex drive can fall. The almost inevitable outcome of this situation is erectile dysfunction. In other words, while creatine can help performance in the weight room, too much of it over too long a period can hinder performance in the bedroom.