Is generic Viagra available? If so, how do I get it? And if not, when will it go on the market?

The first generic formulations of Viagra are scheduled to hit the U.S. market beginning in December 2017. All will be marketed under the name of Viagra’s active ingredient — sildenafil citrate.

Teva Pharmaceuticals USA, the American subsidiary of an Israeli-based drugmaker that specializes in generic drugs, is expected to bring out the first generic version, which could be followed closely by another from Mylan.

Both of these generics have been tentatively approved by the FDA. Such tentative approvals usually don’t become final until the brand-name drug’s patent has expired. In these cases, Pfizer’s patent on Viagra is good until April 2020, but the company has negotiated special licensing deals with both Teva and Mylan that will allow them to introduce generic formulations of the little blue pill early.

In return for early generic rights, Teva and Mylan will have to pay licensing fees to Pfizer until the latter’s patent finally expires in 2020.

What Erectile Dysfunction Medications Can I Take on a Full Stomach?

The drugs used to treat erectile dysfunction are known as PDE-5 inhibitors. A substance called phosphodiesterase type 5 (PDE-5) degrades a circulating compound called cyclic GMP, which is present in the smooth muscle cells lining the blood vessels that supply the penis. By inhibiting the action of PDE-5, more cyclic GMP is available, so conditions are more favorable for an erection in the presence of sexual stimulation.

PDE-5 inhibitors work by mimicking, to an extent, the positive circulatory effects of regular exercise.

Viagra, Levitra, Staxyn (a quick-dissolve formulation of Levitra), and Cialis are good at inhibiting PDE-5, but they’re not 100% selective for that substance, particularly at higher dosages. For example, Viagra, in addition to inhibiting PDE-5, also inhibits PDE-6 and PDE-9.

In fact, it is the inhibition of PDE-6, which is present in the retina of the eye, that is believed to be responsible for vision changes that some men report as a side effect of Viagra. Cialis, in addition to inhibiting PDE-5, also inhibits PDE-11.

All this is a roundabout way of saying that PDE-5 inhibitors are similar, but not identical in action, and the user’s physiology, and how the drugs are taken can have a subtle effect on how well they work and how long they take to be effective. Food can affect the action of some, but not all erectile dysfunction drugs. Here are some frequently asked questions about taking erectile dysfunction medication with food.

How long after taking Viagra should I be able to get an erection?

As previously explained, the active ingredients in Viagra and the other oral ED medications are designed to temporarily restore erectile function in men who are suffering from insufficient blood flow to the penis.

This is by far the most common cause of ED, but it’s not the only cause. If your impotence has its origin in emotional or mental issues and not vascular insufficiency, then it’s unlikely that Viagra will work for you regardless of when you take it.

The same is true of ED that’s caused by traumatic or congenital injury to the blood vessels that supply the male genitals. However, if your erection problems are caused by compromised blood flow to the penis because of atherosclerosis or other physiological causes, Viagra’s active ingredient should kick in as early as 30 minutes after you take it.

If you haven’t responded within 60 minutes after taking the drug, it is possible that the drug won’t work for you. If you’ve tried the drug two or three times without success, you might want to explore other treatment options with your doctor.

What’s the difference between the Viagra I get from the pharmacy and the “herbal Viagra” I see advertised on the internet?

That’s a difficult question to answer because all “herbal Viagra” is not the same. And some so-called herbal Viagra isn’t herbal at all. Because this sort of remedy falls under the very loose heading of dietary supplements, it is not subject to the same strict standards as prescription drugs. When the Food and Drug Administration is advised that a specific dietary supplement has caused problematic reactions, it investigates and usually issues a warning to consumers.

It may also seek to pressure the supplement’s distributor to recall the product. Some of these so-called remedies have been found to contain dangerously high levels of herbal ingredients that sometimes cause adverse side effects in humans. Such herbs include epimedium, more commonly known as horny goat weed, and yohimbine, a crystalline compound derived from the bark of the yohimbe tree. These ingredients are not bad in and of themselves, but some users may be hypersensitive to their effects and find them hard, if not impossible, to tolerate.

In other supplements, testing has determined that they contain varying but unlisted amounts of one or more of the active ingredients found in prescription ED medications. In some cases, the amount of the active ingredient is too little to be effective, while in others it is so high that it could pose a danger.

While the negative publicity caused by one of these FDA consumer warnings may persuade a supplement distributor to withdraw that specific product, it may reappear not long thereafter under a different brand name. For this reason, you should exercise special care in buying and taking dietary supplements. It’s best to purchase only those produced by a well-known and reputable supplement manufacturer. If in doubt, ask your doctor.

What lifestyle factors can I change to improve erectile health as I get older?

You might be surprised at how much influence your lifestyle has on erection health. With around 20 years of history with drugs like Viagra, doctors now know far more about what causes erectile dysfunction, and in most cases, it’s a matter of simple hydraulics: blood flow to the penis becomes insufficient for erections hard enough for sexual activity.

All kinds of lifestyle habits influence how well your circulatory system operates. Smoking is a big one. Smoking narrows blood vessels throughout the body, including the blood vessels that supply your reproductive organs. Quitting helps those blood vessels heal to some extent, and if nothing else, helps keep the problem from getting worse.

Likewise, a fatty diet that clogs up the arteries of your heart clogs up arteries everywhere, and adopting a heart-healthy diet with whole grains, fresh fruits, vegetables, and lean protein can help bring your blood lipid profile in line with what it should be. Exercise too improves circulation, and you don’t have to run marathons. Consistency is essential, however.

If you have diabetes, tighter regulation of your blood glucose can stave off damages to small blood vessels that contribute to erectile dysfunction and helps you feel better overall. In short, all those things your doctor recommends that you do to remain healthy: not smoking, eating healthy, exercising, and closely monitoring chronic health conditions are better for erectile health as well.

A healthy diet and regular physical activity benefit erection health.

I have used Viagra in the past, but I’ve been told that it’s unwise to take more than one Viagra in a 24-hour period. Why is that?

The effects of Viagra last from four to six hours, during which period you should be able to get and keep an erection hard enough for penetration. The recommended starting dose for Viagra is 50 milligrams, but some men may need as much as 100 milligrams to achieve the desired results. After the four- to six-hour period of optimal effectiveness, traces of the drug remain in your system.

Taking another dose within a 24-hour period could combine with this residual amount and result in dangerously low blood pressure, much as one might see from taking Viagra with a nitrate-based drug. For this reason, it’s wise to follow the directions and limit yourself to one dose per day.

I have used Viagra in the past, but I’ve been told that it’s unwise to take more than one Viagra in a 24-hour period. Why is that?

The effects of Viagra last from four to six hours, during which period you should be able to get and keep an erection hard enough for penetration. The recommended starting dose for Viagra is 50 milligrams, but some men may need as much as 100 milligrams to achieve the desired results. After the four- to six-hour period of optimal effectiveness, traces of the drug remain in your system.

Taking another dose within a 24-hour period could combine with this residual amount and result in dangerously low blood pressure, much as one might see from taking Viagra with a nitrate-based drug. For this reason, it’s wise to follow the directions and limit yourself to one dose per day.

Does Cialis work better with or without food?

Cialis lasts significantly longer than Viagra and Levitra – up to 36 hours. Doctors recommend taking Cialis an hour or two before you want to have sex. You can take Cialis with or without food, and you probably won’t notice any difference in its effectiveness.

One thing you should be aware of with Cialis, however, is the effect of alcohol. While a beer or a glass of wine is unlikely to cause problems, heavier drinking while taking Cialis increases your risk of something called orthostatic hypotension, which is a fast drop in blood pressure when you stand up. As a result, you could experience dizziness, headache, and even fainting, along with a faster heartbeat. Furthermore, if you drink heavily while taking Cialis and then stop drinking, your blood pressure can rise very quickly.

These problems are more likely to occur with Cialis than with other drugs for erectile dysfunction, and researchers believe it has something to do with the drug’s long half-life (which is a major selling point for Cialis, by the way).

What are the Differences Between Cialis 36-Hour and Daily Cialis

Cialis was the third of the “big three” erectile dysfunction medications to enter the market, making its debut in 2003. But Cialis wasn’t just an also-ran: in a way, it revolutionized the treatment of erectile dysfunction all over again due to its significantly longer half-life than competitors Levitra and Viagra.

Cialis had something more to offer than its competitors for men with erectile dysfunction.

With a half-life of around 18 hours (compared to 4 to 6 hours for its competitors), a man could take Cialis on a Friday night, and possibly still feel the drug’s effects on Sunday. Cialis, quite naturally, capitalized on this, nicknaming it the “Weekend Pill,” indicating users of the drug could get a weekend’s worth of sexual intimacy from a single Cialis pill.

Sure, the company took some grief over its iconic couple of side-by-side bathtubs watching the sunset, but they laughed all the way to the bank. Cialis became the top-selling erectile dysfunction drug, and even in 2017, on the brink of losing patent protection in the United States and Europe, it remains a blockbuster drug (defined as a drug that brings in $1 billion or more per year in revenue).

Several years ago, Cialis started offering the option of daily Cialis therapy. Instead of taking 5 mg, 10 mg, or 20 mg of Cialis on an as-needed basis, men could take 2.5 mg to 5 mg of Cialis at approximately the same time every day, with the goal being a steady enough level of the drug that sexual spontaneity becomes a real possibility. Here are some frequently asked questions about Cialis daily therapy versus Cialis taken on the traditional as-needed basis.

Does Viagra have side effects and, if so, how serious are they?

Rare is the prescription medication that doesn’t have at least a few adverse side effects, and Viagra is no exception. However, its side effects are generally mild and tend to disappear the longer you take the drug. The most common of these side effects include back pain, diarrhea, dizziness, flushing, headache, muscle ache, nausea, runny or stuffy nose, and upset stomach.

The little blue pill has been known to cause some more serious side effects, but these, fortunately, are rare. Some men have experienced a sudden decrease or total loss of hearing or vision after taking Viagra. Others have reported an erection that lasted for four or more hours. If you should experience any of these more serious side effects, you should seek medical attention immediately.