What is Staxyn and How Does it Work for Erectile Dysfunction?

In June of 2010, GlaxoSmithKline and Merck & Co., Inc. announced that the US Food and Drug Administration (FDA) approved Staxyn as a treatment option for erectile dysfunction. The drug became available later that year. The active ingredient in Staxyn is vardenafil HCl, the same as the active ingredient in Levitra. Staxyn, however, is an orally disintegrating tablet that the user places under the tongue. It dissolves without the necessity of drinking water.

Staxyn contains the ingredient in Levitra, with a different delivery system.

Like Levitra, Staxyn belongs to the class of drugs known as PDE-5 inhibitors. Each orally-disintegrating tablet of Staxyn contains a 10-mg dose of the active ingredient, along with inactive ingredients and flavorings that make it palatable.

What side effects are possible with Staxyn?

The side effect profile of Staxyn is similar to that of Levitra. Less serious side effects that have been reported include a feeling of warmth or redness in the face, chest, or neck, runny or stuffy nose, headache, upset stomach, or back pain.

The most serious side effects are typically signs of an allergic reaction like hives, swelling of the face, tongue, lips, and throat, or difficulty breathing. This is an emergency and requires emergency treatment. Likewise, dizziness, numbness, or tingling in the chest, arms, neck, or jaw should be investigated right away.

Serious side effects that are not necessarily medical emergencies include vision changes, sudden hearing loss or ringing in the ears. If these occur, contact your doctor. You may or may not need emergency treatment.

I know that Viagra is called a PDE5 inhibitor, but I have no idea what that really means. How do drugs of that type work and, more importantly, will Viagra work for me?

Sildenafil citrate, the active ingredient in Cialis, belongs to a family of medications known collectively as PDE5 inhibitors. They are so called because they are able to temporarily sideline an enzyme known as phosphodiesterase-5, which can interfere with blood flow to the penis.

Erections originate in the brain when that organ detects feelings of sexual desire or physical stimuli to the male genitals or other erogenous zones. When the brain receives such signals, it releases a flood of nitric oxide coursing toward the pelvic region, setting off secondary chemical reactions as it goes. One of those reactions triggers the synthesis of a substance known as cyclic guanosine monophosphate or cGMP.

The cGMP, in turn, signals the smooth muscle tissue lining the arteries that supply the penis to relax, and as they do, blood flow through those vessels increases sharply. Once the spongy erectile tissue of the penis has been filled with blood, erection is achieved. To ensure that the erection lasts until sexual activity is complete, the cGMP signals the veins that carry blood away from the penis to constrict, trapping blood in the penis and sustaining the erection.

One of the primary tasks of the PDE5 enzyme is to break down cGMP, which isn’t a serious problem in men with robust vascular systems because more cGMP is created to take its place. However, in men whose vascular systems are already compromised, the PDE5 can overwhelm the cGMP and sabotage the erection. PDE5 inhibitors hold the PDE5 enzyme at bay for four to 36 hours, allowing a window of opportunity for an erection to occur and sexual activity to be completed.

As previously noted, Viagra and the other PDE5 inhibitors are designed primarily to help men suffering from erectile dysfunction caused by insufficient blood flow to the penis, the single largest cause of ED. If your symptoms of ED are psychological in origin or caused by traumatic or congenital damage to your genitals, Viagra might be of little help.

How long does it take for Staxyn to become effective?

Most men find that Staxyn becomes effective in about 15 minutes. That’s faster than the action of traditional Levitra, Viagra, and Cialis. Because it dissolves under the tongue, Staxyn can enter the bloodstream faster than a regular tablet. Still, however, doctors advise taking Staxyn one-half to one hour before sexual activity.

How long do the effects of Staxyn last?

A single dose of Staxyn is designed to last around six hours. However, if you take Staxyn and end up with an erection that lasts longer than four hours, it’s a medical emergency and you need to seek treatment immediately, or you risk permanent damage.

Staxyn can still be effective six or more hours after it’s taken.

What is the Link Between Cialis and Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)

A miniscule fraction of Cialis users reported vision loss. It was generally attributable to other causes, however.

In addition to the relatively minor eye problems of things appearing blue tinted, blurred vision, and difficulty distinguishing between green and blue, there have been a small number of reports of sudden vision loss. In these rare cases, a condition called non-arteritic anterior ischemic optic neuropathy (NAION) has been diagnosed. A total of 43 cases of NAION have been reported among users of erectile dysfunction drugs in the PDE-5 inhibitor class.

More specifically 38 Viagra users have reported it, as have four Cialis users and one Levitra user. This is a tiny number of people compared to the tens of millions of men who have safely taken these drugs over the past decade-plus.

What is the likeliest explanation for the problems?

The problem with attributing NAION to erectile dysfunction drugs like Cialis is that there’s no evidence that it was the drug that caused the vision problem. This form of blindness is among the most common causes of sudden loss of vision in older Americans. An estimated 1,000 to 6,000 cases are reported each year. Older Americans are not only the most likely to experience NAION, they’re the most likely to take drugs like Cialis, Viagra, and Levitra.

Complicating matters further, two of the main conditions that lead to NAION are diabetes and heart disease, which is significant because diabetes and heart disease are two leading causes of erectile dysfunction. In other words, it’s hard to say whether these men would have experienced vision loss if they hadn’t been taking erectile dysfunction drugs.

What is the Link Between Cialis and Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)

A miniscule fraction of Cialis users reported vision loss. It was generally attributable to other causes, however.

In addition to the relatively minor eye problems of things appearing blue tinted, blurred vision, and difficulty distinguishing between green and blue, there have been a small number of reports of sudden vision loss. In these rare cases, a condition called non-arteritic anterior ischemic optic neuropathy (NAION) has been diagnosed. A total of 43 cases of NAION have been reported among users of erectile dysfunction drugs in the PDE-5 inhibitor class.

More specifically 38 Viagra users have reported it, as have four Cialis users and one Levitra user. This is a tiny number of people compared to the tens of millions of men who have safely taken these drugs over the past decade-plus.

What is the likeliest explanation for the problems?

The problem with attributing NAION to erectile dysfunction drugs like Cialis is that there’s no evidence that it was the drug that caused the vision problem. This form of blindness is among the most common causes of sudden loss of vision in older Americans. An estimated 1,000 to 6,000 cases are reported each year. Older Americans are not only the most likely to experience NAION, they’re the most likely to take drugs like Cialis, Viagra, and Levitra.

Complicating matters further, two of the main conditions that lead to NAION are diabetes and heart disease, which is significant because diabetes and heart disease are two leading causes of erectile dysfunction. In other words, it’s hard to say whether these men would have experienced vision loss if they hadn’t been taking erectile dysfunction drugs.

26 Year Old Uncircumcised Having Problems Getting Erection Will Viagra Help

I’m a healthy 26-year-old man who’s uncircumcised. Lately, I’ve been having problems getting and keeping an erection. First, I’m curious to know whether getting circumcised would make it easier — or even more difficult — for me to get an erection. Second, I’m wondering if taking Viagra will help me regardless of whether I’m circumcised or not.

Several studies and systematic reviews of existing scientific literature have been undertaken in an effort to evaluate the effects if any, that circumcision has on male sexual function. A meta-analysis of data from 10 studies covering more than 18,500 men — 9,317 circumcised and 9,413 uncircumcised — produced no evidence that circumcision affects male sexual function in any way.

However, that review, published in the September 2013 issue of the “Asian Journal of Andrology,” acknowledged that the studies analyzed were of uneven quality and suggested that additional “well-designed and prospective studies” be conducted to shed additional light on the effects of circumcision on sexual function.

A more recent study, undertaken to test the hypothesis that male sexual function was somehow inferior after circumcision, failed to produce any evidence to support that theory. The second study, published in the July 2016 issue of the “Danish Medical Journal,” systematically reviewed data covering more than 3,677 men. However, one thing is clear. Circumcision has no effect whatsoever on the workings of Viagra.

The little blue pill might work for you or not, depending on a variety of factors, including the cause of your ED symptoms, but circumcision is not one of those factors.