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There is no single answer to this question, because what works best for some men with ED doesn’t necessarily work as well for others. And for some, the use of any of the PDE5-inhibiting drugs may be inappropriate because of underlying health conditions or because of possible conflicts with other medications they are taking.

All of the PDE5 inhibitors — Viagra, Cialis, Levitra, Staxyn, and Stendra — work in pretty much the same way, although there are some slight differences in how quickly they take effect and some more significant differences in how long they are effective.

If you’re looking for a longer-lasting oral ED drug, your best bet is probably Cialis for Use as Needed, which can be effective for as long as 36 hours, earning it the nickname of the “weekend pill.”

Other medications include those used in penile injection and MUSE therapies. Injected into the erectile tissue of the penis or absorbed through the linings of the urethra, these medications include alprostadil, papaverine, and phenolamine.

When it comes to lifestyle choices, it’s a safe bet that anything that’s bad for your heart is also bad for your penis, according to Andrew McCullough, M.D., director of the male sexual health program at New York University’s Langone Medical Center. And diet is no exception.

Diets low in fruits and vegetables and high in processed foods that are fatty and/or fried impede healthy blood flow throughout the body, negatively impacting the heart and erectile function, according to WebMD. By contrast, the Mediterranean diet is heavily weighted toward fresh fruit and vegetables, red wine, whole grains, and heart-healthy fats such from fish, nuts, and olive oil. WebMD says studies have shown that the incidence of ED among men who follow the Mediterranean diet is very low.

A study published in the May 2010 issue of “The Journal of Sexual Medicine” looked specifically at the effects of adherence to the Mediterranean diet among a group of men diagnosed with type 2 diabetes, a major risk factor for ED. The incidence of ED was significantly lower among test subjects who followed the Mediterranean diet most faithfully.

Known scientifically as the post-ejaculation refractory time, or PERT, the time it takes to get a new
erection after ejaculation varies widely depending on the age of the man. Although hardly scientific, 30 minutes is perhaps the recovery time most commonly cited.

For young men in their 20s, erection recovery time ranges between 5 and 30 minutes, according to Drogo K. Montague, M.D., of the Cleveland Clinic’s Glickman Urological Institute. In an interview with Cosmopolitan, Montague said that the older the man is, the longer it takes to get a second erection.

After a man ejaculates, the muscles in the penile area relax and blood flow to the penis decreases
significantly.

In one of life’s cruel ironies, women don’t need to recharge their sexual batteries between lovemaking
sessions. “As long as she’s aroused and lubricated, a woman is physically capable of having sex as many
times as she wants without a break in between,” Montague told Cosmo.

Another option for treating erectile dysfunction is intraurethral therapy, or as it’s officially known,
medicated urethral system for erections, or MUSE. The medication used in MUSE is alprostadil, which is also one of the drugs used most widely in penile injection therapy. However, MUSE requires no injections.

A small pellet of the medication is introduced into the end of penis, which is known as the urethra, via an applicator consisting of a thin tube at the end of which is the medication. Once the tube is inserted well within the penis, a button on the applicator can be pressed to release the medicated pellet.

Absorbed through the membrane that lines the inside of the urethra, the alprostadil relaxes the blood
vessels that supply the penis, sharply increasing blood flow. An erection usually develops within 10 minutes after the medication is released. The erection almost always lasts for at least 30 minutes and sometimes for up to an hour.

In the late 20th century before the introduction of Viagra, the first of the new wave of ED medications, men looking for ways to treat their ED symptoms had only a couple of options: penile prostheses and penile injection therapy.

According to Boston University School of Medicine, intracavernosal injections gained popularity in the 1980s as a less cumbersome and awkward alternative to penile implants or prostheses. Even with the availability of the new oral ED medications, injection therapy has “withstood the test of time,” according to BU.

This form of therapy involves the self-injection of a small amount of medication directly into the penis’s corpora cavernosa — twin cylinders of spongelike erectile tissue that fill with blood to make an erection.

Your doctor usually administers the first shots to determine optimal dosing level and then supervises as you self-inject the first few times to be sure you’re doing it correctly. Among the medications used
individually or in combination are alprostadil, papaverine, and phenolamine.

Also known as impotence, erectile dysfunction is the inability to get or keep an erection that is firm enough for sexual intercourse, according to AUA Foundation, the foundation of the American Urological Association. While almost all men have an occasional problem achieving and maintaining an erection, the term is most properly used in reference to a chronic pattern of erection difficulties.

While the incidence of ED increases with age, younger men are not immune from the problem, although ED among the young is often psychological in origin rather than physiological.

The risk of ED is greater among those who suffer from underlying medical conditions, such as cardiovascular disease, high blood pressure, diabetes, and obesity. Because both the heart and penis depend on strong blood flow for optimal function, ED sometimes serves as an early warning sign of more serious health problems. Healthy eating and regular exercise can help prevent ED.