I’ve been told that it’s dangerous to take Viagra while also taking nitrate-based drugs. I take a nitroglycerin tablet to relieve the pain of angina as needed, but I’m also struggling with erection problems. How long after taking one drug is it safe to take the other? Or is it unwise for me to use Viagra at all?

You’re probably best off to avoid Viagra altogether. Consult your doctor. The active ingredient in the drug and the nitrates in nitroglycerin pills both work in much the same way, lowering blood pressure to allow improved blood flow. Taking both of these drugs can cause a precipitous drop in blood pressure, which could be life-threatening.

This sharp drop in blood pressure is particularly dangerous for patients who have angina. As blood pressure drops, blood flow to the heart decreases, which can increase the chances of having a heart attack. It should be noted that some angina patients should avoid the physical stress of sexual activity altogether.

While sexual activity is permissible for those with chronic stable angina, those with unstable angina should avoid sex until the causes of their unstable angina have been addressed through cardiac catheterization.

In what ways is Viagra similar to the other erectile dysfunction drugs on the market, and in what ways, if at all, is it different?

All of the oral ED medications now on the market belong to the same family of drugs — PDE5 inhibitors — as Viagra. These include vardenafil hydrochloride in both Levitra and Staxyn, tadalafil in Cialis, and avanafil in Stendra. Although these chemical compounds are very similar in structure, each differs subtly from the others.

Some men with ED symptoms find that all of these drugs produce the desired results for them but may prefer a specific drug because it has fewer if any, side effects or goes to work faster than the others.

Others may find that one of the PDE5 inhibitors doesn’t work for them at all, while the rest do.

If you need an oral ED drug to get and keep an erection, you owe it to yourself to give them all a try to see which is best for you. In the end, it becomes a matter of personal preference. While most of these medications have a duration of action lasting from four to six hours, Cialis for use as needed is the exception. Its effects can last up to 36 hours, setting it apart from the rest of the PDE5 inhibitors now available.

For the last 18 months, I have struggled with recurring bouts of deep depression. During this period, it’s been all but impossible for me to get an erection. Is Viagra likely to help?

Depression can be caused by a wide array of factors, including an inability to function normally sexually. If for example, that is the specific cause of your depression, Viagra might help. However, for most cases of ED that are psychological in origin, PDE5 inhibitors are not the answer.

You’ll need psychological counseling to get to the root of your depression. Once you’ve confronted whatever demons may be causing your depression, you likely will be able to regain normal sexual function.

And you probably will be able to do it without needing pharmaceutical help. However, you should be aware that many of the medications prescribed for the treatment of depression interfere with normal sexual function and don’t work well with Viagra either. Ask your doctor or psychiatrist to prescribe an antidepressant that’s not known to interfere with erectile function.

I know that Viagra is called a PDE5 inhibitor, but I have no idea what that really means. How do drugs of that type work and, more importantly, will Viagra work for me?

Sildenafil citrate, the active ingredient in Cialis, belongs to a family of medications known collectively as PDE5 inhibitors. They are so called because they are able to temporarily sideline an enzyme known as phosphodiesterase-5, which can interfere with blood flow to the penis.

Erections originate in the brain when that organ detects feelings of sexual desire or physical stimuli to the male genitals or other erogenous zones. When the brain receives such signals, it releases a flood of nitric oxide coursing toward the pelvic region, setting off secondary chemical reactions as it goes. One of those reactions triggers the synthesis of a substance known as cyclic guanosine monophosphate or cGMP.

The cGMP, in turn, signals the smooth muscle tissue lining the arteries that supply the penis to relax, and as they do, blood flow through those vessels increases sharply. Once the spongy erectile tissue of the penis has been filled with blood, erection is achieved. To ensure that the erection lasts until sexual activity is complete, the cGMP signals the veins that carry blood away from the penis to constrict, trapping blood in the penis and sustaining the erection.

One of the primary tasks of the PDE5 enzyme is to break down cGMP, which isn’t a serious problem in men with robust vascular systems because more cGMP is created to take its place. However, in men whose vascular systems are already compromised, the PDE5 can overwhelm the cGMP and sabotage the erection. PDE5 inhibitors hold the PDE5 enzyme at bay for four to 36 hours, allowing a window of opportunity for an erection to occur and sexual activity to be completed.

As previously noted, Viagra and the other PDE5 inhibitors are designed primarily to help men suffering from erectile dysfunction caused by insufficient blood flow to the penis, the single largest cause of ED. If your symptoms of ED are psychological in origin or caused by traumatic or congenital damage to your genitals, Viagra might be of little help.

26 Year Old Uncircumcised Having Problems Getting Erection Will Viagra Help

I’m a healthy 26-year-old man who’s uncircumcised. Lately, I’ve been having problems getting and keeping an erection. First, I’m curious to know whether getting circumcised would make it easier — or even more difficult — for me to get an erection. Second, I’m wondering if taking Viagra will help me regardless of whether I’m circumcised or not.

Several studies and systematic reviews of existing scientific literature have been undertaken in an effort to evaluate the effects if any, that circumcision has on male sexual function. A meta-analysis of data from 10 studies covering more than 18,500 men — 9,317 circumcised and 9,413 uncircumcised — produced no evidence that circumcision affects male sexual function in any way.

However, that review, published in the September 2013 issue of the “Asian Journal of Andrology,” acknowledged that the studies analyzed were of uneven quality and suggested that additional “well-designed and prospective studies” be conducted to shed additional light on the effects of circumcision on sexual function.

A more recent study, undertaken to test the hypothesis that male sexual function was somehow inferior after circumcision, failed to produce any evidence to support that theory. The second study, published in the July 2016 issue of the “Danish Medical Journal,” systematically reviewed data covering more than 3,677 men. However, one thing is clear. Circumcision has no effect whatsoever on the workings of Viagra.

The little blue pill might work for you or not, depending on a variety of factors, including the cause of your ED symptoms, but circumcision is not one of those factors.

26 Year Old Uncircumcised Having Problems Getting Erection Will Viagra Help

I’m a healthy 26-year-old man who’s uncircumcised. Lately, I’ve been having problems getting and keeping an erection. First, I’m curious to know whether getting circumcised would make it easier — or even more difficult — for me to get an erection. Second, I’m wondering if taking Viagra will help me regardless of whether I’m circumcised or not.

Several studies and systematic reviews of existing scientific literature have been undertaken in an effort to evaluate the effects if any, that circumcision has on male sexual function. A meta-analysis of data from 10 studies covering more than 18,500 men — 9,317 circumcised and 9,413 uncircumcised — produced no evidence that circumcision affects male sexual function in any way.

However, that review, published in the September 2013 issue of the “Asian Journal of Andrology,” acknowledged that the studies analyzed were of uneven quality and suggested that additional “well-designed and prospective studies” be conducted to shed additional light on the effects of circumcision on sexual function.

A more recent study, undertaken to test the hypothesis that male sexual function was somehow inferior after circumcision, failed to produce any evidence to support that theory. The second study, published in the July 2016 issue of the “Danish Medical Journal,” systematically reviewed data covering more than 3,677 men. However, one thing is clear. Circumcision has no effect whatsoever on the workings of Viagra.

The little blue pill might work for you or not, depending on a variety of factors, including the cause of your ED symptoms, but circumcision is not one of those factors.

I’m over 60. Should I bother trying to get help with erectile dysfunction?

If you want to have sex and have problems with erectile dysfunction, of course you should bother getting help. Most men can take medications like Viagra, and for those who can’t, other treatment options for erectile dysfunction exist, including vacuum pumps, injectable medications, and surgical implants.

And the more you commit to a healthy overall lifestyle, the more successful your doctor will be in treating your erection problems.

Could My Prescription Medications be Contributing to Erection Problems?

Absolutely. Plenty of medications for a range of conditions, including allergies and depression, can cause erection problems or make existing problems worse. Whether you see your regular family doctor or a urologist for erectile dysfunction, it’s critical that you inform him or her of any prescription medications, over-the-counter medications, and supplements that you take on a regular basis. If you are taking medications that are known to affect erection quality, your doctor may be able to prescribe an alternative medication that will have fewer side effects.